Tag archives for Zyprexa

Zyprexa Approved for Treating Manic Depression

Posted By Kelly On Sunday, April 11th 2010   under:  Zyprexa (olanzapine)   Tags: , ,    
Brand Name Drug: Zyprexa Active Ingredient Drug: olanzapine Indication: Treatment of manic depression/bipolar disorder Company Name: Eli Lilly and Company Introduction Manic depression, also called bipolar disorder, afflicts some 4 million Americans. Characterized by severe mood swings between incredible elation and deep depression, the disorder has been difficult to treat. Many patients either do not respond to drug therapy or stop taking their medication because of unwanted side effects. Now a new drug has entered the ... Read More

Zyprexa for Manic Depression

Posted By Kelly On Friday, April 9th 2010   under:  Zyprexa (olanzapine)   Tags: , ,    
Zyprexa Brand Name: Zyprexa Active Ingredient: olanzapine Indication: Treatment of manic depression (bipolar disorder); also approved for schizophrenia Company Name: Eli Lilly and Company Availability: Approved in 1997 for schizophrenia and on March 20, 2000 for manic depression (bipolar disorder) Introduction Bipolar disorder is a lifelong psychiatric disorder that features mood swings between mania and depression, and afflicts some 4 million Americans. Although lithium, valproate, carbamazepine, and antipsychotics have been prescribed to treat the disorder, many patients do not respond to these ... Read More

Treatment-Resistant Schizophrenia May Respond to High-Dose Atypical

Posted By Kelly On Tuesday, April 6th 2010   under:  Pharmacotherapy   Tags: , ,    
Results from a recent study suggest that olanzapine (Zyprexa) given in moderate to high doses may be useful in treating schizophrenia in patients who have shown resistance to trials with other antipsychotic medications. Published in the September 1999 issue of the Canadian Journal of Psychiatry, the prospective, open-label study by Serdar Dursun et al. reported on 16 patients (11 male, five female; mean age 40±7 years) having a documented history of ... Read More

Treating Dementia With Atypical Antipsychotics. Part 2

Posted By Kelly On Tuesday, January 5th 2010   under:  Pharmacotherapy   Tags: , , , , , ,    
Atypical Antipsychotics Most initial published data on atypical antipsychotic drugs in the elderly are clinical trials in nondemented patients with schizophrenia or Parkinson's disease. In the last two to three years, controlled trials evaluating risperidone (Risperdal) and olanzapine (Zyprexa) in patients with dementia have been published. There is now evidence that these two atypical antipsychotic drugs offer efficacy in this patient population with fewer adverse effect concerns than the typical antipsychotic ... Read More

Depression and Psychosis: Improving Outcomes

Posted By Kelly On Monday, December 14th 2009   under:  Depression   Tags: , , , , , ,    
The following is the question and answer session from the Depression and Psychosis: Improving Outcomes. The presenters were Richard G. Petty, M.D., and Jack M. Gorman, M.D. Question: What's the latest on quetiapine and slit lamp examinations? Dr. Petty: As many of you will know, quetiapine was associated with the development of cataracts in dogs during the clinical studies and there have also been case reports of humans getting cataracts. My own ... Read More

How are 5-HT2 selective antagonists different from current drug therapy in schizophrenia?

Posted By Kelly On Friday, December 11th 2009   under:  Pharmacology   Tags: , , , ,    
There a two major classes of agents currently used to treat schizophrenia - the older neuroleptics (typical antipsychotics) and the newer atypical antipsychotics such as clozapine, olanzapine (Zyprexa) and risperidone (Risperdal). The first class of agents is comprised of predominantly dopamine-2 (D2) receptor antagonists, with haloperidol being the prototype. These neuroleptics have little, if any, direct effects on serotonin systems; e.g., haloperidol does not interact appreciably with serotonin-2 (5-HT2) receptors. ... Read More

“Old” vs. “New” Medications

Posted By Kelly On Saturday, November 28th 2009   under:  Question - Answer   Tags: , , , ,    
Question. My 18-year-old son was diagnosed schizophrenic two years ago. Currently hospitalized, he is receiving clozapine and Haldol as anti-psychotics and Paxil for depression. He was moved directly to clozapine from Risperdal and has gained over 60 lbs. in three months. I've heard that olanzapine acts much like clozapine, but with fewer side effects. Is it normal to move to "older" drugs before exhausting newer ones? Answer. I appreciate how confusing ... Read More

Zyprexa (Olanzapine) and Depression

Posted By Kelly On Thursday, November 26th 2009   under:  Question - Answer   Tags: , ,    
Question. Has there been any testing yet of the efficacy of olanzapine (Zyprexa) for depression? Do you think its profile indicates that it might be a good drug for the mood disorders? Answer. I am not aware of published studies of olanzapine (Zyprexa) specifically for the treatment of depressed subjects. As you know, this agent is FDA-labeled for use in psychotic disorders, mainly schizophrenia. However, Lilly Research Lab does have data ... Read More

Episodic Depression Treatment

Posted By Kelly On Tuesday, November 17th 2009   under:  Question - Answer   Tags: , , , , , , ,    
Episodic Depression Treatment Q. I have been trying to deal with my depression, anxiety and posstraumatic stress disorder for 10 years. About nine months out of the year, I feel low-grade depressed, but I am more or less functional. Two or three times a year, I get swamped with episodes of major depression, hopelessness, sleep panic attacks, unreasonable fears and intense suicidal ideation. I become essentially nonfunctional for about three or ... Read More
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