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• Antidepressants

  • Fluoxetine Hydrochlonde. Uses. Preparations
    Uses and Administration Prevention of the reuptake of monoamine transmitters such as serotonin, which potentiates their action in the brain, appears to be associated with antidepressant activity. SSRIs such as fluoxetine preferentially inhibit the [...]
  • Fluoxetine Hydrochlonde. Precautions. Interactions
    Precautions Because of their epileptogenic effect SSRIs should be used with caution in patients with epilepsy or a history of such disorders (and should be avoided if the epilepsy is poorly controlled). Treatment should [...]
  • Fluoxetine Hydrochlonde. Adverse Effects
    Drug Approvals (BANM, US Adopted Name, rINNM) International Nonproprietary Names (INNs) in main languages (French, Latin, Spanish): Synonyms: Fluoksetiinihydrokloridi; Fluoksetino hidrochloridas; Fluoxetin-hidroklorid; Fluoxetin-hydrochlorid; Fluoxetina, hidrocloruro de; Fluoxetinhydroklorid; Fluoxetini Hydrochloridum; LY-110140; Lilly-103472 BAN: Fluoxetine Hydrochloride [...]
  • Escitalopram Oxalate
    (British Approved Name Modified, US Adopted Name, rINNM) Drug Nomenclature INNs in main languages (French, Latin, Russian, and Spanish): Synonyms: S-Citalopram Oxalate; Escitalopram, oxalato de; Lu-26-054/0 BAN: Escitalopram Oxalate [BANM] USAN: Escitalopram Oxalate INN: Escitalopram Oxalate [rINNM (en)] INN: [...]
  • Dosulepin Hydrochloride
    Drug Approvals (British Approved Name Modified, rINNM) INNs in main languages (French, Latin, Spanish): Synonyms: Dosulepiinihydrokloridi; Dosulepin-hydrochlorid; Dosulepina, hidrocloruro de; Dosulepinhydroklorid; Dosulepini Hydrochloridum; Dosulepino hidrochloridas; Doszulepin-hidroklorid; Dothiepin Hydrochloride BAN: Dosulepin Hydrochloride [BANM] USAN: Dothiepin Hydrochloride INN: [...]
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• Pharmacotherapy

  • Case: Antidepressant agents. Questions – Answers
    Questions [1] Which of the following agents is contraindicated in a patient with epilepsy? A. Bupropion B. Fluoxetine C. Mirtazapine D. Venlafaxine [2] The antidepressant action of imipramine is thought to be caused by which of the following? A. Blockade [...]
  • Case: Antidepressant agents. Discussion
    Class Drugs used to treat depression are classified as TCAs, atypical heterocyclic (second- and third-generation) agents, SSRIs, and monoamine oxidase inhibitors (MAOIs). Other conditions for which certain antidepressant agents are used include panic disorder, [...]
  • Case: Antidepressant agents
    A 30-year-old woman presents to your office for the evaluation of fatigue. For the past 2 months she has felt run down. She says that she doesn’t feel like participating in activities that [...]
  • Treatment-Resistant Schizophrenia May Respond to High-Dose Atypical
    Results from a recent study suggest that olanzapine (Zyprexa) given in moderate to high doses may be useful in treating schizophrenia in patients who have shown resistance to trials with other antipsychotic medications. Published [...]
  • Treating Dementia With Atypical Antipsychotics. Part 2
    Atypical Antipsychotics Most initial published data on atypical antipsychotic drugs in the elderly are clinical trials in nondemented patients with schizophrenia or Parkinson’s disease. In the last two to three years, controlled trials evaluating [...]
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• Drugs

  • Drug interactions: cytochrome P450. Part 8
    Role of Pharmacist There is no guide, chart, or computer software program for clinicians to clearly identify or quickly predict which drugs interact with the CYP enzymes and create clinically significant [...]
  • Drug interactions: cytochrome P450. Part 7
    CYP2C Isoenzyme Metabolism The CYP2C subfamily consists of 2C9, 2C10, and 2C19 isozymes as well as others. While these enzymes metabolize a smaller number of drugs, many of these drugs are involved [...]
  • Drug interactions: cytochrome P450. Part 6
    CYP1A2 Isoenzyme Metabolism Approximately 15% of all drugs used today are metabolized by the CYP1A2 isozyme. It is generally believed that there is no genetic polymorphism involved with this isozyme. Common [...]
  • Drug interactions: cytochrome P450. Part 5
    CYP2D6 Isoenzyme Metabolism About 25% of all drugs used today are substrates for the CYP2D6 isozyme. This isozyme has been studied extensively. It greatly exhibits genetic polymorphism; certain individuals will lack [...]
  • Drug interactions: cytochrome P450. Part 4
    CYP3A4 Isoenzyme Metabolism The CYP3A enzyme family is composed of four isozymes involved with metabolism: CYP3A, CYP3A4, CYP3A5, and CYP3A7. Of these, the CYP3A4 isozyme is the most common; however, these enzymes are so [...]
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• Treatment of Depression

  • Depression Interventions Effective
    Depression treatment in the United States has been getting a bad name in a number of quarters recently. Patients who responded to Caredata.com’s 1999 Commercial Health Plan Survey, for example, ranked treatment of [...]
  • St. John’s Wort and the Treatment of Depression
    Historically, St. John’s wort has been used as an herbal remedy for depression, anxiety, diuresis, gastritis and insomnia. Recent studies demonstrate that the extract, primarily hypericin, is a strong, and nearly irreversible, inhibitor [...]