Question. I recently heard of the use of a low dose of Thorazine for the treatment of depression. Are you familiar with this treatment? Answer. I am not aware of any controlled, persuasive evidence that Thorazine (chlorpromazine) or any standard antipsychotic - in low doses or high - is particularly effective as an antidepressant. The exception to this claim may be in so-called delusional depression, in which psychotic features are present; ... Read More