Research question Is sertraline (Zoloft) effective at improving the symptoms and reducing the functional impairment associated with premenstrual dysphoric disorder (PMDD)? Type of article and design Prospective, multicentre, double-blind, randomized placebo-controlled trial. Relevance to family physicians As defined by DSM-IV criteria, PMDD has a group of physical and behavioural symptoms that occur during the premenstrual period and are severe enough to interfere with work, usual activities, and relationships. Premenstrual ... Read More