Depression Symptoms Treatment

December 13th, 2009 by admin

Antidepressants Exacerbating Hypertension

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Question. I have a problem with antidepressants exacerbating my hypertension. Are there any that don’t increase blood pressure? Are there new antidepressants that might soon be available?

Answer. There are many antidepressants that do not increase blood pressure for MOST adults, but there are always exceptions. For example, the older tricyclic antidepressants (such as imipramine or nortriptyline) typically result in decreased blood pressure. (Children can sometimes have hypertensive reactions to some of the tricyclics, as do a minority of adults). The new antidepressant nefazodone (Serzone) is also unlikely to raise blood pressure, and often will reduce it. This is also true of its close cousin trazodone (Desyrel). Although the MAOIs (monoamine oxidase inhibitors) are associated with hypertensive reactions (very high blood pressure) when an individual goes off the special MAOI diet, these drugs also generally reduce blood pressure. The antidepressants that are most likely to raise blood pressure are venlafaxine (Effexor) and bupropion (Wellbutrin), but this reaction can often be controlled by adjusting the patient’s blood pressure medication.

There is a new antidepressant called citalopram that is expected to be released shortly. It is in the same general class as Prozac and Zoloft (the “SSRIs”), and I have not seen any data yet on its blood pressure effects. My suggestion is to discuss the use of either nefazodone (Serzone) or trazodone (Desyrel) with your doctor.

Synonyms of Citalopram:

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