Patient Evaluation

Once the safety of the patient and those around him is assured, a thorough evaluation is needed to identify contributing factors and to prevent further episodes. Medical, psychiatric and medication histories are core to an effective evaluation. Physicians, nurses, and pharmacists should participate using their particular expertise. Contributing factors may become clear after reviewing the patient’s psychiatric history, especially if noncompliance, substance abuse, or psychosocial stressors coexist. A mental status exam identifying underlying symptoms, such as hallucinations or delusional thinking, will further guide treatment. Patients who develop agitation two to three weeks after starting antipsychotic treatment should be evaluated for akathisia as a potential underlying cause. When the cause is unknown, physical examinations and laboratory tests that identify common causes of aggression due to a general medical condition are undertaken (Table 3). The need for a specific test is based on the patient’s presentation, physical findings, and medical history. The social context and environmental precipitants surrounding the aggression are also important to explore. During the initial assessment of all patients, it is important to determine their specific risk for aggression, even if they are currently calm, as preventable measures may be taken to minimize risk.

Table 3. Common Tests to Identify Medical
Causes of Agitation and Aggression

General examinations:
History and physical
Neurological examination
Medication history
Mental status examination

Common Laboratory Tests
Urine drug screen
Blood alcohol concentration
General chemistry panel
CBC with differential
Urinalysis
Urine culture and sensitivity
Serum drug concentrations
Thyroid profile
HIV test

Other tests
Chest X-ray
EEG, MRI or CT scan (head trauma,
brain tumors and epilepsy stroke)
Lumbar puncture


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