Depression Symptoms Treatment

November 22nd, 2009 by admin

Managing Resistant Depression. Part 7

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Other augmentation strategies. In addition to lithium, other agents have

been described as augmentors, depending on the antidepressant used.

Triiodothyronine: The thyroid hormone potentiation of tricyclics can be useful. The thyrotropin-releasing hormone stimulation test should be done first to rule out Grade III (subclinical) hypothyroidism. If hypothyroidism is present to any degree, it should be treated with thyroid replacement. If the patient is euthyroid, low doses of triiodothyronine (25 to 50 µg/d) can be added to the tricyclic for a limited period (10 to 14 days). One third of depressed patients will respond; women are more likely to respond than men.

Tricyclic and MAOI combination: Some evidence suggests that, in some patients, this combination is more effective than either drug used alone. Ideally, both drugs should be started simultaneously or the MAOI added to a tricyclic regimen. The safest combination seems to be phenelzine and either amitriptyline or doxepin. Clomipramine, imipramine, and the new heterocyclic agents, such as fluoxetine, should be avoided. Low doses are recommended initially and rigid adherence to dietary orders is necessary.

Tricyclic and fluoxetine combination: Some reports indicate that, if fluoxetine is added to a tricyclic, such as desipramine, it will produce a robust and rapid response in many patients. This augmentation effect could be due to fluoxetine’s ability to increase tricyclic levels through a reduction of hepatic oxidation or a facilitation of the speed with which tricyclic antidepressants decrease or down regulate the sensitivity of the postsynaptic receptor. Because fluoxetine can raise blood levels of tricyclics, serum levels should be routinely measured. Although reports do not agree, the combination of fluoxetine and MAOIs should probably be avoided.

L-Tryptophan: L-Tryptophan is the dietary precursor of brain serotonin. Reports have confirmed its ability to enhance the antidepressant effect of MAOIs, as well as tricyclics and lithium. Doses in excess of 3 to 4 g daily are required, which makes this approach cumbersome and costly.

Intramuscular reserpine and tricyclics combination: Reserpine disrupts the reuptake mechanism of intraneuronal storage vesicles and stimulates the synthesis and release of amines. Used alone, reserpine can lead to amine depletion and cause depression. Used in conjunction with a tricyclic, reserpine does not cause amine depletion because of the reuptake-inhibiting action of the tricyclic. Therapeutic synergism can be achieved. Reserpine (7 to 10 mg) is given intramuscularly for 2 days; a rapid response is often seen.

Anticonvulsants. Drugs such as carbamazepine have proven effective in the prophylaxis of bipolar disorder. Some evidence suggests that an antidepressant action also takes place. Carbamazepine can be useful in combination with antidepressants, particularly in bipolar patients. Sodium valproate and clonazepam can have a similar effect.

Cognitive therapy: Cognitive therapy, a specific psychotherapeutic technique, can be useful in treating chronic depression (dysthymia) or as an augmentation strategy in conjunction with pharmacotherapy. Several studies have demonstrated the effectiveness of cognitive therapy, which is relatively easy to learn. With this technique, a depressed patient is encouraged to examine negative cognitions or views of the world, to analyze and dissect these into smaller, manageable specifics, and to change them. This can lead to positive thinking and a change of mood.

Psychostimulants: Dextroamphetamine, methylphenidate, and, to a lesser degree, magnesium pemoline all have mood-elevating, psychoenergizing properties. They have a place in the management of mood disorders. These drugs are helpful in combination with antidepressants or when used alone. Elderly apathetic, or medically ill, depressed patients often respond to psychostimulants when the side effects of antidepressants cannot be tolerated. Psychostimulants are also useful for patients who do not respond to any antidepressants and are truly treatment resistant. There is no evidence of addiction or dose escalation, although clearly this class of drugs must be prescribed with caution and monitored with care.

Miscellaneous approaches: A list of less frequently used antidepressant therapies, many of which are based on anecdotal evidence only, follows for the sake of providing an exhaustive overview of possible approaches. Administered by a specialist, the following therapies could be useful: light therapy, for treating seasonal affective disorder; sleep deprivation, which can lead to mood elevation lasting for several days, particularly in bipolar patients; high-dose tricyclic or MAOI therapy, which should only be given if serum levels can be monitored; intravenous clomipramine or maprotiline, which allows for rapid perfusion of the central nervous system and avoids first-pass liver metabolism; bromocriptine; estrogen therapy for post-menopausal women; and psychosurgery.

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