
Histamine
The distribution in the human brain of neurons and their projections (arrows) containing histamine.

Histamine
The distribution in the human brain of neurons and their projections (arrows) containing histamine.

Serotonin
The distribution in the human brain of neurons and their projections (arrows) containing serotonin.

Bladder - Urinary Retention
Noradrenergic innervation of the urinary tract via sympathetic neurons leaving the spinal cord regulates bladder emptying via alpha 1 receptors.

Heart - Tachycardia
Noradrenergic innervation of the heart via sympathic neurons leaving the spinal cord regulates cardiovascular function, including heart rate, via beta 1 receptors.

Brainstem - Blood Pressure
Brainstem norepinephrine in cardiovascular centers controls blood pressure.

Cerebellum - Tremor
The noradrenergic projection from the locus coeruleus to the cerebellum may mediate motor movements, especially tremor.

Limbic - Energy Level, Agitation, Emotions
The noradrenergic projection from the locus coeruleus to limbic cortex may mediate emotions, as well as energy, fatigue, and psychomotor agitation or psychomotor retardation.

Frontal 2 - Attention
Other noradrenergic projections from the locus coeruleus to frontal cortex are thought to mediate the effects of norepinephrine on attention, concentration, and other cognitive functions, such as working memory and the speed of information processing. Alpha 2 postsynaptic receptors may be important in transducing postsynaptic signals regulating attention in postsynaptic target neurons.

Frontal 1 - Depression
Some noradrenergic projections from the locus coeruleus to frontal cortex are thought to be responsible for the regulatory actions of norepinephrine on mood. Beta 1 postsynaptic receptors may be important in transducing noradrenergic signals regulating mood in postsynaptic targets.

Norepinephrine
The distribution in the human brain of neurons and their projections (arrows) containing catecholamine neurotransmitters.