Depression Symptoms Treatment » Prozac (Fluoxetine)

Fluoxetine Hydrochlonde. Uses. Preparations

admin — Fri, 27 Aug 2010 04:09:13 +0000

Uses and Administration Prevention of the reuptake of monoamine transmitters such as serotonin, which potentiates their action in the brain, appears to be associated with antidepressant activity. SSRIs such as fluoxetine preferentially inhibit the reuptake of serotonin compared with noradrenaline, and have limited direct action at other neurotrans-mitter sites, including muscarinic receptors. They therefore cause fewer antimuscarinic or sedative adverse effects than the tricyclic antidepressants and are less cardiotoxic. Citalopram is the most selective of the SSRIs currently available, whereas paroxetine is the most potent. SSRIs provide an alternative to the tricyclics for the treatment of depression. As with the tricyclics, it may be several weeks before an antidepressant effect is seen. Once depression has then resolved, maintenance therapy should be continued for at least 4 to 6 months (12 months in the elderly) to avoid relapse on stopping therapy. Patients with a history of recurrent depression should continue to receive maintenance treatment for at least 5 years and possibly indefinitely. Some Read more [...]

Fluoxetine Hydrochlonde. Precautions. Interactions

admin — Thu, 26 Aug 2010 04:07:39 +0000

Precautions Because of their epileptogenic effect SSRIs should be used with caution in patients with epilepsy or a history of such disorders (and should be avoided if the epilepsy is poorly controlled). Treatment should be stopped if seizures develop or when there is an increase in seizure frequency. Care is advised in patients receiving ECT as prolonged seizures have occurred rarely. SSRIs should also be used with caution in patients with cardiac disease or a history of bleeding disorders. Although SSRIs are preferred to tricyclics for the treatment of depression in patients with diabetes, they may alter glycaemic control and therefore caution is also warranted in diabetic subjects. SSRIs should be used with caution in patients with angle-closure glaucoma. Fluoxetine should be stopped in patients who develop a rash since systemic effects, possibly related to vasculitis, have occurred in such patients. Fluoxetine undergoes hepatic metabolism and should be used with caution and in reduced doses in patients with impaired hepatic function. Patients should be closely monitored during early therapy Read more [...]

Fluoxetine Hydrochlonde. Adverse Effects

admin — Wed, 25 Aug 2010 04:05:55 +0000

Drug Approvals (BANM, US Adopted Name, rINNM) International Nonproprietary Names (INNs) in main languages (French, Latin, Spanish): Synonyms: Fluoksetiinihydrokloridi; Fluoksetino hidrochloridas; Fluoxetin-hidroklorid; Fluoxetin-hydrochlorid; Fluoxetina, hidrocloruro de; Fluoxetinhydroklorid; Fluoxetini Hydrochloridum; LY-110140; Lilly-103472 BAN: Fluoxetine Hydrochloride [BANM] USAN: Fluoxetine Hydrochloride INN: Fluoxetine Hydrochloride [rINNM (en)] INN: Hidrocloruro de fluoxetina [rINNM (es)] INN: Fluoxétine, Chlorhydrate de [rINNM (fr)] INN: Fluoxetini Hydrochloridum [rINNM (la)] INN: Флуоксетина Гидрохлорид [rINNM (ru)] Chemical name: (±)-N-Methyl-3-phenyl-3-(α,α,α-trifluoro-p-tolyloxy)propylamine hydrochloride Molecular formula: C17H18F3NO,HCl =345.8 CAS: 54910-89-3 (fluoxetine); 59333-67-4 (fluoxetine hydrochloride) ATC code: N06AB03 Read code: y026e Note. The following terms have been used as 'street names' or slang names for various forms of fluoxetine: Distas; Green and whites; Greens; Limes; Pros; Zacs. Pharmacopoeias. In Europe and US. European Pharmacopoeia, Read more [...]

Antidepressant drug Prozac therapy for bulimia nervosa

admin — Sat, 16 Jan 2010 14:16:38 +0000

A recent report suggests that the antidepressant drug Prozac (fluoxetine) can be useful in the treatment of bulimia nervosa.

* Researchers at the New York State Psychiatric Institute reviewed findings from 15 controlled studies on the use of anticonvulsants, lithium, fenfluramine and antidepressants in bulimia patients to reach their conclusions; patients in the studies used vomiting to compensate for food intake, were of normal weight, were predominately female, and were young adults.

* Found that only antidepressant therapy – particularly with fluoxetine – was consistently shown to reduce the frequency of binge eating among normal-weight patients with bulimia nervosa.

* Authors suggest that bulimia patients should demonstrate six months of real improvement before any effort is made to discontinue any antidepressant drug therapy.

Indications for Use of Antidepressants All antidepressants are indicated for the treatment of acute major depressive episodes; there is also evidence for their use in the prevention and relapse and recurrence. In addition, a number of more minor forms of depression may also respond to antidepressant medication, including dysthymic ...
Selective Serotonin Reuptake Inhibitors in Children The safety and effectiveness of most drugs are generally not as well established during clinical trials in children as in adults. Consequently, there is limited controlled research on the use of selective serotonin reuptake inhibitors (SSRIs) in children for the ...
Adolescent depression. Diagnosis. Part 4 Comorbidity Comorbidity is the simultaneous occurrence of more than one diagnosis. Comorbidity complicates research on the etiology and outcome of a single diagnosis, such as depression, because the comorbid diagnosis might in fact be the main determinant of outcome. Table ...
SSRI (Prozac – fluoxetine) Use and Suicidal Behavior There has been continuing speculation about a relationship between fluoxetine (Prozac) use and increased suicidal behavior since six cases were reported in 1990, which were followed by several other similar case reports. However, subsequent retrospective analyses of large patient samples, surveys of psychiatrists, and ...
Adolescent depression. Treatment. Part 4 Pharmacotherapy Antidepressant medication has been surprisingly inefficacious for adolescents. In contrast to open studies, placebo-controlled, double-blinded research protocols have failed to demonstrate any benefit of medication over placebo for adolescent depression. Up to 60% of adolescents recover while receiving placebo; up ...

SSRI (Prozac – fluoxetine) Use and Suicidal Behavior

admin — Tue, 15 Dec 2009 07:55:55 +0000

There has been continuing speculation about a relationship between fluoxetine (Prozac) use and increased suicidal behavior since six cases were reported in 1990, which were followed by several other similar case reports. However, subsequent retrospective analyses of large patient samples, surveys of psychiatrists, and re-analysis of many clinical studies of fluoxetine and other newer antidepressant drugs failed to find such a relationship. In 1999, Leon et al. reported a prospective, naturalistic 15-year follow-up study from the National Institute of Mental Health Collaborative Depression Study. Analyses of this study focused on data from the time fluoxetine was available in the United States. Since case reports, retrospective studies, randomized clinical trials and surveys of prescribers all have limitations as to applicability to the general population of patients taking fluoxetine (Prozac), this NIMH study, with its close and frequent clinical assessments, offered the unique opportunity to evaluate this issue in a naturalistic treatment setting. Method The study focused on 643 subjects who were Read more [...]

Drugs and ‘Talk Therapy’ Compared in Teen Depression

admin — Mon, 09 Nov 2009 10:28:25 +0000

Study shows decrease in suicidal thoughts from combined therapy. A study funded by the National Institute of Mental Health (NIMH) concludes that Prozac is more effective in treating depression in teenagers than so-called talk therapy, but the two combined show the best treatment results. The NIMH has been conducting research to help clarify the potential value and risks of antidepressants and to explore how drug therapy compares with psychotherapy in adolescent depression. The multisite controlled clinical trial — the Treatment for Adolescents with Depression Study (TADS) — was launched in the late 1990s to directly compare the efficacy of fluoxetine, cognitive behavior therapy, and a combination of the two. The findings come amid controversy over the use of antidepressants in children and the possible link between antidepressants and the risk of suicide in children and teenagers. In this study of 439 adolescents suffering from moderate to severe depression, 71% responded well to the combined treatment. The researchers also found a dramatic decrease in the amount of suicidal thinking, although Read more [...]

Prozac Lessens Premenstrual Dysphoric Disorder Symptoms

admin — Mon, 09 Nov 2009 06:53:34 +0000

Drug lessens severity of premenstrual dysphoria.

Intermittent dosages of fluoxetine (Prozac/Lilly) given during the luteal phase of the menstrual cycle may help women suffering from PMDD (premenstrual dysphoric disorder), studies suggest. Premenstrual dysphoric disorder, a severe variant of premenstrual syndrome, affects 3%-5% of women during their reproductive years, causing depression, anxiety, tension, lability, and irritability. A review of 12 clinical trials led researchers to conclude that, at 20 mg/day, fluoxetine reduces mood symptoms, physical symptoms, and social impairment in women with premenstrual dysphoric disorder and is well-tolerated.

Premenstrual Dysphoric Disorder. Part 3 PMS/PMDD SYMPTOMS Premenstrual syndrome affects as many as 75% of women of reproductive age at some point in their life. However, studies have not defined an exact age-group or time course for this syndrome to occur. But one study suggests that the 25 to ...
Premenstrual Dysphoric Disorder. Part 1 SM is a 24-year-old Asian Indian female who presents to her gynecologist with a chief complaint of "severe abdominal pain, breast tenderness, headaches, and weight gain" during her menstrual cycle. She states that her cramps feel like "pins through her stomach." Her boyfriend states ...
Premenstrual Dysphoric Disorder. Part 2 ETIOLOGY AND PATHOPHYSIOLOGY While many studies have focused on the predisposing factors related to premenstrual dysphoric disorder, the relative contributions to this disorder are unclear. Small studies of monozygotic twins have suggested a hereditary link to premenstrual symptoms. Other considerations include a patient's onset of ...
Zoloft Helps premenstrual syndrome (PMS) Antidepressant relieves severe menstrual symptoms. Women suffering from a severe form of premenstrual syndrome were helped by Zoloft, according to a study of 200 women in a dozen medical centers. About 62% of the women showed "much or very much improvement" compared with 34% given ...
Abbreviation AE - Adverse Event CRF - Case Report Form DCT - Demethylcitalopram DDCT - Didemethyl Metabolite DSU - Drug Surveillance Unit ECG - Electrocardiogram ISS - Integrated Summary of Safety PMDD - Premenstrual Dysphoric Disorder PMS - Premenstrual Syndrome SAE - Serious Adverse Event SIADH - Syndrome of Inappropriate Antidiuretic Hormone SSRI - Selective Serotonin ...