Depression Symptoms Treatment » Celexa (Citalopram)

Citalopram

admin — Sat, 17 Jul 2010 13:27:26 +0000

Drug Approvals (British Approved Name, rINN) Synonyms: Citalopram; Citalopramum; Lu-10-171; Sitalopraami BAN: Citalopram INN: Citalopram [rINN (en)] INN: Citalopram [rINN (es)] INN: Citalopram [rINN (fr)] INN: Citalopramum [rINN (la)] INN: Циталопрам [rINN (ru)] Chemical name: 1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Molecular formula: C20H21FN2O =324.4 CAS: 59729-33-8 ATC code: N06AB04 Citalopram Hydrobromide (British Approved Name Modified, rINNM) Drug Nomenclature Synonyms: Citalopram, hidrobromuro de; Lu-10-171B; Nitalapram Hydrobromide BAN: Citalopram Hydrobromide [BANM] USAN: Citalopram Hydrobromide INN: Citalopram Hydrobromide [rINNM (en)] INN: Hidrobromuro de citalopram [rINNM (es)] INN: Citalopram, Bromhydrate de [rINNM (fr)] INN: Citaloprami Hydrobromidum [rINNM (la)] INN: Циталопрама Гидробромид [rINNM (ru)] Molecular formula: C20H21FN2O,HBr =405.3 CAS: 59729-32-7 Pharmacopoeias. In US. The United States Pharmacopeia 31, 2008 (Citalopram Hydrobromide). A white to almost white, crystalline powder. Freely soluble Read more [...]

Celexa: SSRI, Popular in Europe, Approved for Depression

admin — Mon, 30 Nov 2009 02:38:10 +0000

Citalopram (Celexa, Forest Laboratories, Parke-Davis) has been approved by FDA for treatment of depression. A highly selective serotonin reuptake inhibitor, citalopram is the best-selling antidepressant in 13 countries, including eight in Europe. Citalopram has proven effective in treatment of depression in clinical trials involving 23,000 patients and has been used in some 8 million patients in 64 countries where the drug is already approved. Two, six-month, double-blind, placebo-controlled studies indicated that citalopram is significantly more effective than placebo in preventing relapse of depression.

Side effects include nausea, dry mouth, and sleepiness. As with all SSRIs, citalopram should not be taken with monoamine oxidase inhibitors.

Celexa (Citalopram): Drug-Drug Interactions Concomitant administration of imipramine, lithium, and levomepromazine had no effect on Tmax values of citalopram or its metabolites. In contrast, cimetidine caused a statistically significant decrease in the Tmax value of citalopram and an increase in that of DCT. In an evaluation of the effects ...
Celexa (Citalopram): Proposed Directions for Use Directions for use conveyed in the sponsor's proposed labeling are as follows: Citalopram should be administered at a dose of 20 mg once daily. Clinical trials demonstrating antidepressant effectiveness studied the recommended therapeutic dose range of 20-60 mg/day. Patients not responding to 20 mg may ...
Citalopram Drug Approvals (British Approved Name, rINN) Synonyms: Citalopram; Citalopramum; Lu-10-171; Sitalopraami BAN: Citalopram INN: Citalopram [rINN (en)] INN: Citalopram [rINN (es)] INN: Citalopram [rINN (fr)] INN: Citalopramum [rINN (la)] INN: Циталопрам [rINN (ru)] Chemical name: 1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Molecular formula: C20H21FN2O =324.4 CAS: 59729-33-8 ATC code: N06AB04 Citalopram Hydrobromide (British Approved Name Modified, rINNM) Drug Nomenclature Synonyms: Citalopram, hidrobromuro de; Lu-10-171B; ...
SSRIs. Forest Laboratories Definition of Depression A diagnosis of major depressive disorder is made if an individual has five or more of the following symptoms during the same two-week period. The symptoms may vary from person to person but often include: a persistent sad mood loss of interest or pleasure ...
Vestra: Drug for the Treatment of Depression Brand Name: Vestra Active Ingredient: reboxetine mesylate Indication: Treatment of depression Company Name: Pharmacia & Upjohn Vestra: Introduction As a selective norepinephrine reuptake inhibitor (SNRI), Vestra is the first of a new class of antidepressant drugs. This new mechanism of action appears to produce fewer side effects, such as ...

Celexa (Citalopram): Drug-Drug Interactions

admin — Thu, 24 Sep 2009 17:59:33 +0000

Concomitant administration of imipramine, lithium, and levomepromazine had no effect on Tmax values of citalopram or its metabolites. In contrast, cimetidine caused a statistically significant decrease in the Tmax value of citalopram and an increase in that of DCT. In an evaluation of the effects of psychotropic drugs on serum citalopram concentrations in psychiatric patients, individual neuroleptics (perphenazine, thioridazine, periciazin, chlorpromazine, haloperidol, zuclopenthixol, and levomepromazine) had no effect on serum citalopram or its demethyl derivative. Only alprazolam among the benzodiazepines tested (including oxazepam, diazepam, temazepam, clonazepam, lorazepam, chlorazepam, and chlordiazepoxide) had any effect on citalopram and DCT concentrations, increasing them by 20% and 48%, respectively. Among the antidepressants administered concomitantly with citalopram, clomipramine exerted the most effect, increasing citalopram and DCT concentrations by 94% and 250%, respectively. Concomitant administration of cimetidine caused a significant increase in the average steady-state levels Read more [...]

Celexa (Citalopram): Proposed Directions for Use

admin — Thu, 24 Sep 2009 13:32:10 +0000

Directions for use conveyed in the sponsor’s proposed labeling are as follows:

Citalopram should be administered at a dose of 20 mg once daily. Clinical trials demonstrating antidepressant effectiveness studied the recommended therapeutic dose range of 20-60 mg/day. Patients not responding to 20 mg may benefit from dose increases, in 20 mg/day increments, up to a maximum of 60 mg/day. Dose changes should occur at intervals of at least one week.

Citalopram should be administered once daily, in the morning or evening, with or without food.

In elderly patients, dosage should not exceed 40 mg/day. In patients with hepatic impairment, dosage should not exceed 40 mg/day. No dosage adjustment is necessary for patients with mild or moderate renal impairment, but should be used with caution in patients with severe renal impairment.

Review book: Speaking of sadness Speaking of sadness. Depression, disconnection, and the meanings of illness David A. Karp Oxford University Press Canada, 1996, 240 pp Strengths Excellent description of isolation and disconnection of sufferers. Excellent bibliography. Weaknesses Philosophical discussion might not interest everyone. Pharmacologic treatment and its outcomes ...
Gross anatomy of the forebrain
Gross anatomy of the forebrain
(A) Cerebral hemisphere surface anatomy, showing the four lobes of the brain and the major sulci and gyri. The ventricular system and basal ganglia can also be seen in this phantom view. (B) Midsagittal view showing the ...
Somatotopic organization of sensory information
Somatotopic organization of sensory information
(Top) The locations of primary and secondary somatosensory cortical areas on the lateral surface of the brain. (Bottom) Cortical representation of different regions of skin.
Histamine
Histamine
The distribution in the human brain of neurons and their projections (arrows) containing histamine.
Serotonin
Serotonin
The distribution in the human brain of neurons and their projections (arrows) containing serotonin.