Depression Symptoms Treatment
Archive for the ‘Antidepressants’ Category
Drug Approvals
(British Approved Name Modified, US Adopted Name, rINN)
International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):
Synonyms: CP-51974-01; CP-51974-1; Sertralina, hidrocloruro de
BAN: Sertraline Hydrochloride [BANM]
USAN: Sertraline Hydrochloride
INN: Sertraline Hydrochloride [rINNM (en)]
INN: Hidrocloruro de sertralina [rINNM (es)]
INN: Sertraline, Chlorhydrate de [rINNM (fr)]
INN: Sertralini Hydrochloridum [rINNM (la)]
INN: Сертралина Гидрохлорид [rINNM (ru)]
Chemical name: (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl(methyl)amine hydrochloride
Molecular formula: C17H17Cl2N,HCl =342.7
CAS: 79617-96-2 (sertraline); 79559-97-0 (sertraline hydrochloride)
ATC code: N06AB06
Note. The following terms have been used as 'street names' or slang names for various forms of sertraline: Z's Zloft Zoomers.
Pharmacopoeias. In Europe.
European Pharmacopoeia, 6th ed. (Sertraline Hydrochlonde). A white or almost white, crystalline powder, ft exhibits polymorphism. Slightly soluble in water freely soluble in anhydrous alcohol Read more [...]
Drug Nomenclature
Synonyms: FCE-20124 (reboxetine or reboxetine mesilate); PNU-155950E; Reboxetina, mesilato de; Reboxetine Mesylate
BAN: Reboxetine Mesilate [BANM]
USAN: Reboxetine Mesylate
INN: Reboxetine Mesilate [rINNM (en)]
INN: Mesilato de reboxetina [rINNM (es)]
INN: Réboxétine, Mésilate de [rINNM (fr)]
INN: Reboxetini Mesilas [rINNM (la)]
INN: Ребоксетина Мезилат [rINNM (ru)]
Chemical name: (±)-(2RS)-2-[(αRS)-α(2-Ethoxyphenoxy)benzyl]morpholine methanesulphonate
Molecular formula: C19H23NO3,CH4O3S =409.5
CAS: 71620-89-8; 98769-81-4 (both reboxetine); 98769-82-5; 98769-84-7 (both reboxetine mesilate)
ATC code: N06AX18
Adverse Effects
Adverse effects most commonly seen with reboxetine include insomnia, dry mouth, constipation, and increased sweating. Disturbance of visual accommodation, loss of appetite, vertigo, tachycardia, palpitations, vasodilatation, orthostatic hypotension, urinary hesitancy or retention (mainly in men), and erectile dysfunction including ejaculatory delay are also reported as being common adverse reactions. There have been reports of allergic Read more [...]
Drug Nomenclature
Synonyms: MK-240; Protriptilina, hidrocloruro de
BAN: Protriptyline Hydrochloride [BANM]
USAN: Protriptyline Hydrochloride
INN: Protriptyline Hydrochloride [rINNM (en)]
INN: Hidrocloruro de protriptilina [rINNM (es)]
INN: Protriptyline, Chlorhydrate de [rINNM (fr)]
INN: Protriptylini Hydrochloridum [rINNM (la)]
INN: Протриптилина Гидрохлорид [rINNM (ru)]
Chemical name: 3-(5H-Dibenzo[a,d]cyclohept-5-enyl)propyl(methyl)amine hydrochloride
Molecular formula: C19H21N,HCl =299.8
CAS: 438-60-8 (protriptyline); 1225-55-4 (protriptyline hydrochloride)
ATC code: N06AA11
Read code: y025a
Pharmacopoeias. In British and US.
BP 2008 (Protriptyline Hydrochloride). A white to yellowish-white, odourless or almost odourless, powder. Freely soluble in water, in alcohol, and in chloroform practically insoluble in ether A 1% solution in water has a pH of 5.0 to 6.5.
The United States Pharmacopeia 31, 2008 (Protriptyline Hydrochloride). A white to yellowish powder. Is odourless or has not more than a slight odour. Soluble 1 in 2 of water, 1 in 3.5 of alcohol, and Read more [...]
Drug Approvals
(British Approved Name Modified, US Adopted Name, rINN)
International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):
Synonyms: 38489; Nortriptilin-hidroklorid; Nortriptilina, hidrocloruro de; Nortriptilino hidrochloridas; Nortriptyliinihydrokloridi; Nortriptylin-hydrochlorid; Nortriptylinhydroklorid; Nortriptylini Hydrochloridum
BAN: Nortriptyline Hydrochloride [BANM]
USAN: Nortriptyline Hydrochloride
INN: Nortriptyline Hydrochloride [rINNM (en)]
INN: Hidrocloruro de nortriptilina [rINNM (es)]
INN: Nortriptyline, Chlorhydrate de [rINNM (fr)]
INN: Nortriptylini Hydrochloridum [rINNM (la)]
INN: Нортриптилина Гидрохлорид [rINNM (ru)]
Chemical name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl(methyl)amine hydrochloride
Molecular formula: C19H21N,HCl =299.8
CAS: 72-69-5 (nortriptyline); 894-71-3 (nortriptyline hydrochloride)
ATC code: N06AA10
Read code: y00VT [Enuresis]
Pharmacopoeias. In Europe, Japan, and US.
European Pharmacopoeia, 6th ed. (Nortriptyline Hydrochloride). A white or almost white powder. Sparingly Read more [...]
Drug Nomenclature
Synonyms: DU-23000; Fluvoksamiinimaleaatti; Fluvoxamina, maleato de; Fluvoxamini Maleas; Fluvoxaminmaleat
BAN: Fluvoxamine Maleate [BANM]
USAN: Fluvoxamine Maleate
INN: Fluvoxamine Maleate [rINNM (en)]
INN: Maleato de fluvoxamina [rINNM (es)]
INN: Fluvoxamine, Maléate de [rINNM (fr)]
INN: Fluvoxamini Maleas [rINNM (la)]
INN: Флувоксамина Малеат [rINNM (ru)]
Chemical name: (E)-5-Methoxy-4´-trifluoromethylvalerophenone O-2-aminoethyloxime maleate
Molecular formula: C15H21F3N2O2,C4H4O4 =434.4
CAS: 54739-18-3 (fluvoxamine); 61718-82-9 (fluvoxamine maleate)
ATC code: N06AB08
Read code: y026Z
Pharmacopoeias. In Europe and US.
European Pharmacopoeia, 6th ed. (Fluvoxamine Maleate). A white or almost white, crystalline powder. Sparingly soluble in water freely soluble in alcohol and in methyl alcohol.
The United States Pharmacopeia 31, 2008 (Fluvoxamine Maleate). A white to off-white, crystalline powder. Sparingly soluble in water freely soluble in alcohol and in chloroform practically insoluble in solvent ether. Protect from light.
Adverse Effects, Treatment, and Read more [...]
Drug Approvals
(British Approved Name, US Adopted Name, rINN)
INNs in other languages (French, Latin, and Spanish):
Synonyms: BRL-29060; FG-7051; Paroksetiini; Paroxetin; Paroxetinum
BAN: Paroxetine
USAN: Paroxetine
INN: Paroxetine [rINN (en)]
INN: Paroxetina [rINN (es)]
INN: Paroxétine [rINN (fr)]
INN: Paroxetinum [rINN (la)]
INN: Пароксетин [rINN (ru)]
Chemical name: (-)-trans-5-(4-p-Fluorophenyl-3-piperidylmethoxy)-1,3-benzodioxole
Molecular formula: C19H20FNO3 =329.4
CAS: 61869-08-7
ATC code: N06AB05
Paroxetine Hydrochloride
Drug Approvals
(British Approved Name Modified, rINNM)
International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):
Synonyms: BRL-29060A; Paroksetiinihydrokloridihemihydraatti; Paroksetino hidrochloridas hemihidratas; Paroxetin hydrochlorid; Paroxetina, hidrocloruro de; Paroxetine Hydrochloride Hemihydrate; Paroxetinhydrokloridhemihydrat; Paroxetini Hydrochloridum; Paroxetini Hydrochloridum Hemihydricum
BAN: Paroxetine Hydrochloride [BANM]
INN: Paroxetine Hydrochloride [rINNM (en)]
INN: Hidrocloruro de paroxetina [rINNM (es)]
INN: Read more [...]
Drug Approvals
(British Approved Name Modified, US Adopted Name, rINN)
International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):
Synonyms: AF-1161; Trazodona, hidrocloruro de
BAN: Trazodone Hydrochloride [BANM]
USAN: Trazodone Hydrochloride
INN: Trazodone Hydrochloride [rINNM (en)]
INN: Hidrocloruro de trazodona [rINNM (es)]
INN: Trazodone, Chlorhydrate de [rINNM (fr)]
INN: Trazodoni Hydrochloridum [rINNM (la)]
INN: Тразодона Гидрохлорид [rINNM (ru)]
Chemical name: 2-[3-(4-m-Chlorophenylpiperazin-1-yl)propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
Molecular formula: C19H22ClN5O,HCl =408.3
CAS: 19794-93-5 (trazodone); 25332-39-2 (trazodone hydrochloride)
ATC code: N06AX05
Read code: y025f
Note. The following terms have been used as 'street names' (see p.vi) or slang names for various forms of trazodone hydrochloride: Sleepeasy.
Pharmacopoeias. In British and US.
BP 2008 (Trazodone Hydrochloride). A white or almost white crystalline powder. Soluble in water sparingly soluble in alcohol practically insoluble in ether. A 1% solution Read more [...]
Uses and Administration
Prevention of the reuptake of monoamine transmitters such as serotonin, which potentiates their action in the brain, appears to be associated with antidepressant activity. SSRIs such as fluoxetine preferentially inhibit the reuptake of serotonin compared with noradrenaline, and have limited direct action at other neurotrans-mitter sites, including muscarinic receptors. They therefore cause fewer antimuscarinic or sedative adverse effects than the tricyclic antidepressants and are less cardiotoxic. Citalopram is the most selective of the SSRIs currently available, whereas paroxetine is the most potent.
SSRIs provide an alternative to the tricyclics for the treatment of depression. As with the tricyclics, it may be several weeks before an antidepressant effect is seen. Once depression has then resolved, maintenance therapy should be continued for at least 4 to 6 months (12 months in the elderly) to avoid relapse on stopping therapy. Patients with a history of recurrent depression should continue to receive maintenance treatment for at least 5 years and possibly indefinitely.
Some Read more [...]
Drug Approvals
(BANM, US Adopted Name, rINNM)
International Nonproprietary Names (INNs) in main languages (French, Latin, Spanish):
Synonyms: Fluoksetiinihydrokloridi; Fluoksetino hidrochloridas; Fluoxetin-hidroklorid; Fluoxetin-hydrochlorid; Fluoxetina, hidrocloruro de; Fluoxetinhydroklorid; Fluoxetini Hydrochloridum; LY-110140; Lilly-103472
BAN: Fluoxetine Hydrochloride [BANM]
USAN: Fluoxetine Hydrochloride
INN: Fluoxetine Hydrochloride [rINNM (en)]
INN: Hidrocloruro de fluoxetina [rINNM (es)]
INN: Fluoxétine, Chlorhydrate de [rINNM (fr)]
INN: Fluoxetini Hydrochloridum [rINNM (la)]
INN: Флуоксетина Гидрохлорид [rINNM (ru)]
Chemical name: (±)-N-Methyl-3-phenyl-3-(α,α,α-trifluoro-p-tolyloxy)propylamine hydrochloride
Molecular formula: C17H18F3NO,HCl =345.8
CAS: 54910-89-3 (fluoxetine); 59333-67-4 (fluoxetine hydrochloride)
ATC code: N06AB03
Read code: y026e
Note. The following terms have been used as 'street names' or slang names for various forms of fluoxetine: Distas; Green and whites; Greens; Limes; Pros; Zacs.
Pharmacopoeias. In Europe and US.
European Pharmacopoeia, Read more [...]