Brand Name Drug: Zyprexa
Active Ingredient Drug: olanzapine
Indication: Treatment of manic depression/bipolar disorder
Company Name: Eli Lilly and Company
Introduction
Manic depression, also called bipolar disorder, afflicts some 4 million Americans. Characterized by severe mood swings between incredible elation and deep depression, the disorder has been difficult to treat. Many patients either do not respond to drug therapy or stop taking their medication because of unwanted side effects.
Now a new drug has entered the arena: Zyprexa (olanzapine), manufactured by Eli Lilly. Zyprexa had already been approved for the treatment of schizophrenia, and recently got the green light from the FDA for use in patients with manic depression.
Clinical Study Results
Studies evaluating the effectiveness of the drug in patients with acute mania showed that those who took Zyprexa (olanzapine) achieved a significantly greater improvement in their symptoms than patients who received a placebo. Other studies have shown that Zyprexa is as effective as lithium, another agent commonly used to treat manic depression.
What You Should Know
Like other drugs in its class, Zyprexa does have side effects, including dry mouth and weight gain. Drowsiness and dizziness have also been associated with Zyprexa, so patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that they will not experience these effects. Because there are other potential side effects, patients with manic depression who are interested in Zyprexa (olanzapine) should consult their physicians.
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